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Updated: Jan 21, 2026
16:15
Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
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Nonvascularized human skin chronic allograft rejection
Samuel Rotman1, Nathalie Koch2, Lucie Wiesner2
1Service of Clinical Pathology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.
Summary
A patient experienced late-onset chronic rejection of a skin allograft 10-25 years post-transplant, characterized by antibody-mediated and cellular rejection. This case highlights delayed immunopathology in skin allograft recipients.
Area of Science:
- Immunology
- Transplantation Medicine
- Dermatology
Background:
- Skin allografts are used to treat extensive burns.
- Cyclosporine monotherapy was administered for two months post-transplantation.
- Graft failure typically occurs earlier than observed in this case.
Observation:
- A 65-year-old man developed ulcers on his lower extremities 10-25 years after receiving a split-thickness skin allograft.
- Surgical debridement was necessary to address the ulcerations.
- Tissue analysis revealed chronic antibody-mediated and cellular rejection.
Findings:
- Extensive fibrosis and diffuse capillary C4d deposits were noted in the allograft.
- A donor-specific antibody, anti-DRB1*08:01, was identified.
- These findings indicate a late-onset chronic rejection process.
Implications:
- This case presents a unique clinical scenario of delayed chronic rejection in human skin allografts.
- Understanding late-stage rejection mechanisms is crucial for improving long-term graft survival.
- Further research into the immunopathology of chronic allograft rejection is warranted.
Keywords:
accommodationalloantibodyclinical research/practiceethics and public policyorgan transplantation in generalpathology/histopathologyrejection: antibody-mediated (ABMR)surgical techniquetolerancevascularized composite and reconstructive transplantationMore Related Videos
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