Related Experiment Video
Updated: Jan 21, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Epigenetic regulation of POMC; implications for nutritional programming, obesity and metabolic disease
T Candler1, P Kühnen2, A M Prentice1
1MRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, London, UK.
Abstract:
Proopiomelanocortin (POMC) is a key mediator of satiety. Epigenetic marks such as DNA methylation may modulate POMC expression and provide a biological link between early life exposures and later phenotype. Animal studies suggest epigenetic marks at POMC are influenced by maternal energy excess and restriction, prenatal stress and Triclosan exposure. Postnatal factors including energy excess, folate, vitamin A, conjugated linoleic acid and leptin may also affect POMC methylation. Recent human studies suggest POMC DNA methylation is influenced by maternal nutrition in early pregnancy and associated with childhood and adult obesity. Studies in children propose a link between POMC DNA methylation and elevated lipids and insulin, independent of body habitus. This review brings together evidence from animal and human studies and suggests that POMC is sensitive to nutritional programming and is associated with a wide range of weight-related and metabolic outcomes.
More Related Videos
08:30Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
Published on: March 15, 2018
13:03Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
Published on: June 3, 2016
Related Concept Videos
Epigenetic Regulation
Epigenetic Regulation
X-chromosome...
Regulation of Metabolism
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
The Roles of Bacteria and Fungi in Plant Nutrition
Obesity