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Updated: Jan 21, 2026

Visualization of Endoplasmic Reticulum Subdomains in Cultured Cells
Published on: February 18, 2014
Endoplasmic reticulum stress mediated the xanthohumol induced murine melanoma B16-F10 cell death
Yi-Ming Zhang1, Xiao-Bing Shi1, Bo Xu1
1Center for Mitochondria and Healthy Ageing, College of Life Sciences, Yantai University, Yantai 264005, China.
Abstract:
Xanthohumol (XN) exerts a specific cytotoxicity in B16-F10 melanoma cells with cytoplasmic vacuoles formation. Further investigation showed XN inhibited cell proliferation in a time- and dose-dependent manner along with down-regulation of mitogen-activated protein kinase and up-regulation of the endoplasmic reticulum (ER) stress marker Bip, CHOP and protein ubiquitination, which was relieved by the ER-stress inhibitor 4-PBA. Whereas no early apoptosis characteristics was identified during XN induced cell death. [Formula: see text].
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