Association of Subclinical Thyroid Dysfunction with Chronic Kidney Disease: A Systematic Review and Meta-analysis

Background: The association of subclinical thyroid dysfunction (SCTD) with chronic kidney disease (CKD) among community population remains inconclusive. Our aim was to evaluate the association between SCTD and the risk of CKD by conducting a meta-analysis.Methods: Multiple databases were searched to identify studies on the association between SCTD and risk of CKD, up to October 2018. Relevant information for analysis was extracted. A random-effects model was used to calculate the pooled risk estimate.Results: Eight articles were included in this meta-analysis, with three cohort and five cross-sectional studies. The pooled odds ratio (OR) of subclinical hypothyroidism for CKD was 1.37 (95% CI: 1.13-1.67, P = .000, n = 8) in a multivariable-adjusted model. A significant association was observed in subgroup younger than 70 years (OR = 1.40, 95% CI: 1.09-1.79, P = .000, n = 6), but not in subgroup older than 70 years (OR = 1.28, 95% CI: 0.89-1.83, P = .186, n = 2). For subclinical hyperthyroidism, the summary OR was 1.16 (95%CI: 0.97-1.39, P = .115, n = 5) and subgroup analyses by age and study design did not alter the results significantly.Conclusions: Our findings demonstrated that subclinical hypothyroidism was significantly associated with a higher risk of CKD independent of some conventional risk factors among community population and age might have modifying effects on the association.