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Relationship between ALDH2 genotype and in-stent restenosis in Chinese Han patients after percutaneous coronary

Lizhi Lv1, Weijie Ye2, Peiyuan Song2

  • 1Department of Cardiothoracic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People's Republic of China.

BMC Cardiovascular Disorders
|July 27, 2019
PubMed

Insights

The aldehyde dehydrogenase 2 (ALDH2) genotype is not linked to in-stent restenosis (ISR) after coronary artery intervention. However, the ALDH2*2 allele showed a significant association with complications in diabetic patients undergoing PCI.

Area of Science:

  • Cardiovascular Genetics
  • Pharmacogenomics
  • Medical Diagnostics

Background:

  • Coronary artery disease (CAD) is a significant health concern.
  • Percutaneous coronary intervention (PCI) is a common treatment for CAD.
  • In-stent restenosis (ISR) is a major complication following PCI.

Purpose of the Study:

  • To investigate the association between aldehyde dehydrogenase 2 (ALDH2) genotype and ISR.
  • To determine if ALDH2 polymorphisms influence the risk of ISR after PCI.

Main Methods:

  • A cohort of 531 patients undergoing PCI was studied.
  • ALDH2 polymorphisms were identified using polymerase chain restriction fragment length polymorphism (PCR-RFLP) and sequencing.
  • One-year follow-up data was collected to diagnose ISR.

Main Results:

  • No significant correlation was found between ALDH2 genotype and ISR occurrence post-PCI.
  • A significant association was observed between ALDH2 genotype and ISR in diabetic patients.
  • Diabetes emerged as a significant risk factor for ISR.

Conclusions:

  • The ALDH2*2 allele does not appear to be a risk factor for ISR one year after PCI.
  • ALDH2 genotype may play a role in ISR complications among diabetic patients.
  • Larger studies are needed to confirm these findings and establish consensus.
Abstract

Keywords:
ALDH2Genetic polymorphismsIn-stent restenosisPercutaneous coronary interventionSNP

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