Integrating Organs-on-Chips: Multiplexing, Scaling, Vascularization, and Innervation.
DoYeun Park1, Jaeseo Lee1, Justin J Chung2
1KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.
Trends in Biotechnology
|July 27, 2019
Summary
Multiplexed organs-on-chips (OoCs) integrate multiple OoCs for advanced disease modeling and drug discovery. Challenges in scaling, vascularization, and innervation must be overcome for in vivo-like functionality.
Area of Science:
- Biomedical Engineering
- Tissue Engineering
- Drug Discovery
Background:
- Organs-on-chips (OoCs) are microfluidic devices that mimic human organ functions.
- Integrating multiple OoCs offers enhanced capabilities for complex biological modeling.
Purpose of the Study:
- To review the current state of multiplexed organs-on-chips.
- To identify key challenges hindering the in vivo-like operation of integrated OoC systems.
Main Methods:
- Literature review of multiplexed organs-on-chips.
- Analysis of challenges including scaling, vascularization, and innervation.
Main Results:
- Multiplexed OoCs show promise for disease modeling and drug discovery.
- Significant challenges exist in integrating multiple OoCs for seamless in vivo-like function.
Conclusions:
- Future organs-on-chips will feature increased predictive power for in vivo phenomena.
- Integrated OoC systems are poised to become mainstream tools in biomedical and pharmaceutical research.
Keywords:
innervation-on-a-chipintegrated organ-on-a-chipmultiplexingorgan-on-chipscaling rulesvascularization-on-a-chipMore Related Videos
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