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Updated: Jan 21, 2026

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

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Suppression of Prostate Cancer Pathogenesis Using an MDA-9/Syntenin (SDCBP) PDZ1 Small-Molecule Inhibitor

Swadesh K Das1,2,3, Timothy P Kegelman4, Anjan K Pradhan4

  • 1Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia. paul.fisher@vcuhealth.org swadesh.das@vcuhealth.org.

Molecular Cancer Therapeutics
|July 27, 2019
PubMed

Insights

A novel small molecule inhibitor targeting MDA-9/Syntenin (SDCBP) shows promise for treating prostate cancer. This inhibitor effectively blocked tumor cell invasion and migration, suggesting therapeutic potential for various cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Drug Discovery

Background:

  • Metastasis is a leading cause of cancer-related death in solid tumors.
  • MDA-9/Syntenin (SDCBP) is a pro-metastatic and pro-angiogenic gene implicated in prostate cancer pathogenesis.
  • MDA-9/Syntenin interacts with IGF-1R, activating STAT3 and regulating cancer progression.

Purpose of the Study:

  • To evaluate the therapeutic potential of a small molecule inhibitor targeting the PDZ1 domain of MDA-9/Syntenin (PDZ1i).
  • To assess the efficacy of PDZ1i in preclinical models of prostate cancer.

Main Methods:

  • Development of PDZ1i using fragment-based drug discovery (FBDD) guided by NMR spectroscopy.
  • In vitro and in vivo studies to evaluate the anti-cancer activity of PDZ1i.
  • Assessment of tumor cell invasion, migration, and metastasis.

Main Results:

  • PDZ1i demonstrated good in vivo tolerability and a half-life of 9 hours.
  • PDZ1i exhibited significant preclinical anti-prostate cancer activity in vivo.
  • PDZ1i effectively inhibited tumor cell invasion and migration in vitro and metastasis in vivo.

Conclusions:

  • PDZ1i is a specific small-molecule inhibitor of the MDA-9/Syntenin PDZ1 domain.
  • PDZ1i displays therapeutic potential for prostate cancer and potentially other cancers with elevated MDA-9/Syntenin levels.

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