Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Indicators02:39

Indicators

59.7K
Certain organic substances change color in dilute solution when the hydronium ion concentration reaches a particular value. For example, phenolphthalein is a colorless substance in any aqueous solution with a hydronium ion concentration greater than 5.0 × 10−9 M (pH < 8.3). In more basic solutions where the hydronium ion concentration is less than 5.0 × 10−9 M (pH > 8.3), it is red or pink. Substances such as phenolphthalein, which can be used to determine the pH of a solution, are...
59.7K
Mechanical Ventilation I: Indication and Settings01:29

Mechanical Ventilation I: Indication and Settings

2.7K
Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
2.7K
Respiratory Assessment: Purpose and Indications01:19

Respiratory Assessment: Purpose and Indications

1.7K
Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
1.7K
Bioequivalence of Drugs: Drugs with Multiple Indications01:09

Bioequivalence of Drugs: Drugs with Multiple Indications

154
The concept of therapeutic equivalence (TE) in drugs with multiple indications is complex. A generic drug may be therapeutically equivalent to a brand-name product for one specific indication, but this doesn't necessarily mean it's equivalent for all other indications. Evidence of TE in one patient group and bioequivalence shown in healthy volunteers can support—but not confirm—TE for other indications. However, definitive proof requires individual clinical studies for each...
154
Cardiovascular Drugs: Classification based on Therapeutic Indications01:18

Cardiovascular Drugs: Classification based on Therapeutic Indications

4.1K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
4.1K
Stimulants01:29

Stimulants

863
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
863

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Validation of automated image-guided programming in STN-DBS for Parkinson's disease.

Frontiers in human neuroscience·2026
Same author

Comparison of Comprehensive Serum miRNA Sequencing and Apolipoprotein A2 Isoforms for Early Detection of Pancreatic Cancer.

Cancers·2026
Same author

Hallucinations and cognitive impairment are associated with blood pressure fluctuations in Parkinson's disease.

BMJ neurology open·2026
Same author

Midbrain length by the one-line method predicts motor outcome after deep brain stimulation in Parkinson's disease.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

Astrocyte-vascular interactions are disturbed in cerebral white matter of adult-onset neuronal intranuclear inclusion disease.

Journal of neuropathology and experimental neurology·2026
Same author

Contrasting Effects of Deep Brain Stimulation and Intravenous Levodopa on Local Field Potentials.

Movement disorders : official journal of the Movement Disorder Society·2026

Related Experiment Video

Updated: Jan 21, 2026

Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

14.6K

[Indication for Deep Brain Stimulation].

Yasushi Shimo1, Atsushi Umemura, Nobutaka Hattori

  • 1Department of Research and Therapeutics for Movement Disorders, Juntendo University Department of Neurology, Juntendo University Graduate School of Medicine.

Brain and Nerve = Shinkei Kenkyu No Shinpo
|July 27, 2019
PubMed
Summary
This summary is machine-generated.

Deep brain stimulation (DBS) offers effective management for Parkinson's disease motor fluctuations. Patient-specific factors, including disease progression and psychiatric status, are crucial when considering DBS therapy timing and indications.

More Related Videos

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
05:44

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

7.9K
A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

15.7K

Related Experiment Videos

Last Updated: Jan 21, 2026

Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

14.6K
Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
05:44

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

7.9K
A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

15.7K

Area of Science:

  • Neurology
  • Neurosurgery
  • Movement Disorders

Background:

  • Parkinson's disease (PD) presents significant motor fluctuations.
  • Various management strategies exist for PD.
  • Deep brain stimulation (DBS) is a key therapeutic option for PD.

Purpose of the Study:

  • To discuss the role of DBS in managing motor fluctuations in Parkinson's disease.
  • To address the controversies surrounding the indications and timing of DBS induction therapy.
  • To emphasize a personalized approach to DBS therapy selection.

Main Methods:

  • Review of existing literature on DBS for Parkinson's disease.
  • Analysis of factors influencing DBS therapy decisions.
  • Discussion of clinical considerations for patient management.

Main Results:

  • Deep brain stimulation (DBS) is an established and effective treatment for motor fluctuations in Parkinson's disease.
  • Current indications and optimal timing for initiating DBS therapy remain subjects of debate.
  • A comprehensive patient assessment is necessary for optimal outcomes.

Conclusions:

  • DBS is a valuable tool for managing Parkinson's disease motor fluctuations.
  • Therapeutic decisions for DBS should integrate motor symptoms, disease trajectory, and psychological factors.
  • Personalized patient evaluation is paramount for successful DBS implementation.