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Updated: Jan 21, 2026

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
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Circular RNA hsa_circ_0007142 Is Upregulated and Targets miR-103a-2-5p in Colorectal Cancer

Chang-Li Zhu1, Xiaofeng Sha2, Yuan Wang1

  • 1Department of Medical Oncology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an City, Jiangsu Province 223300, China.

Journal of Oncology
|July 27, 2019
PubMed

Insights

Circular RNAs (circRNAs) are upregulated in colorectal cancer (CRC), promoting tumor growth by targeting miR-103a-2-5p. Silencing hsa_circ_0007142 inhibits CRC cell proliferation and metastasis.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are key regulators of gene expression, often acting as microRNA sponges.
  • Aberrant circRNA expression is implicated in various diseases, including cancer.

Purpose of the Study:

  • To investigate the role of circRNAs in colorectal cancer (CRC).
  • To identify specific circRNAs involved in CRC progression and their underlying mechanisms.

Main Methods:

  • CircRNA microarray analysis of CRC tissues and adjacent normal tissues.
  • Bioinformatic analysis and luciferase reporter assays to determine target interactions.
  • In vitro experiments using siRNA to silence circRNA expression and assess effects on CRC cell behavior.

Main Results:

  • Identified 892 differentially expressed circRNAs in CRC, with hsa_circ_0007142 significantly upregulated.
  • hsa_circ_0007142 upregulation correlated with poor differentiation and lymphatic metastasis in CRC patients.
  • hsa_circ_0007142 was found to target miR-103a-2-5p.
  • Silencing hsa_circ_0007142 reduced proliferation, migration, and invasion of CRC cells (HT-29 and HCT-116).

Conclusions:

  • hsa_circ_0007142 is a significantly upregulated circRNA in colorectal cancer.
  • hsa_circ_0007142 promotes CRC progression by targeting miR-103a-2-5p.
  • hsa_circ_0007142 represents a potential therapeutic target for colorectal cancer.

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