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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Acute Coronary Syndrome I: Introduction01:30

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Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
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Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...
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Nephrotic Syndrome II : Assessment and Medical Management01:26

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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
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[Antisynthetase syndromes].

Jutta Bauhammer1, Christoph Fiehn2

  • 1Abteilung für Innere Medizin/Rheumatologie, ACURA-Rheumazentrum Baden-Baden, Rotenbachtalstr. 5, 76530, Baden-Baden, Deutschland. J.Bauhammer@acura-kliniken.de.

Zeitschrift Fur Rheumatologie
|July 27, 2019
PubMed
Summary
This summary is machine-generated.

Antisynthetase syndromes (ASS) are rare autoimmune diseases characterized by myositis, lung disease, and arthritis, along with specific antibodies. The Jo-1 antibody is most common, and treatment depends on organ involvement, with Jo-1 syndrome having a good prognosis.

Keywords:
Antisynthetase antibodiesInterstitial lung diseaseJo-1Mechanic’s handsPolymyositis

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Area of Science:

  • Rheumatology
  • Immunology
  • Pulmonology

Background:

  • Antisynthetase syndromes (ASS) are rare autoimmune disorders.
  • Key features include myositis, interstitial lung disease (ILD), arthritis, and specific autoantibodies.
  • ILD is a significant cause of morbidity and mortality in ASS.

Purpose of the Study:

  • To provide an overview of Antisynthetase Syndromes.
  • To highlight the clinical manifestations and diagnostic markers.
  • To discuss treatment strategies and prognosis based on organ involvement.

Main Methods:

  • Review of existing literature on Antisynthetase Syndromes.
  • Analysis of clinical characteristics associated with different autoantibodies.
  • Evaluation of treatment approaches and survival rates.

Main Results:

  • Eleven aminoacyl-tRNA synthetase autoantibodies are known, with 8 associated with ASS.
  • The Jo-1 antibody is the most prevalent.
  • Treatment efficacy varies with the extent of organ involvement.

Conclusions:

  • ASS diagnosis relies on clinical symptoms and autoantibody detection.
  • The Jo-1 antibody is linked to the best prognosis among ASS.
  • Personalized immunosuppressive therapy is crucial for managing ASS.