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Related Experiment Videos

Novel Screening Tests for Barrett's Esophagus.

Don C Codipilly1, Prasad G Iyer2,3

  • 1Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

Current Gastroenterology Reports
|July 27, 2019
PubMed
Summary

Screening for Barrett's esophagus (BE), a precursor to esophageal adenocarcinoma (EAC), is crucial. Emerging non-endoscopic methods show promise for early detection in high-risk individuals.

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Patient-Reported Barriers to On-Time Surveillance After Successful Endoscopic Eradication of Barrett's Esophagus Neoplasia: A Multicenter Qualitative Interview Study.

Clinical and translational gastroenterology·2026

Area of Science:

  • Gastroenterology
  • Oncology
  • Diagnostic Medicine

Background:

  • Esophageal adenocarcinoma (EAC) incidence has risen sharply.
  • Barrett's esophagus (BE) is the sole known precursor to EAC.
  • Early detection via screening and surveillance aims to improve patient outcomes.

Purpose of the Study:

  • To review current and developing screening methodologies for BE.
  • To assess the potential of novel diagnostic approaches for BE and EAC.

Main Methods:

  • Review of recommended and investigational BE screening techniques.
  • Evaluation of minimally invasive and non-invasive diagnostic strategies.

Main Results:

  • Unsedated transnasal endoscopy offers office-based visualization and biopsy.
Keywords:
Barrett’s esophagusEsophageal adenocarcinomaScreening tests

Related Experiment Videos

  • Developing non-endoscopic methods utilize cell sampling with biomarkers (e.g., trefoil factor 3, methylated DNA, microRNAs).
  • Investigating volatile organic compounds and foregut microbiome for non-invasive detection.

    • Conclusions:

    • Non-invasive diagnostic techniques show significant promise for BE detection.
    • These methods may effectively screen high-risk populations for BE and early EAC.