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Updated: Jan 21, 2026
05:06
A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
Published on: October 24, 2015
12.8K
Epidemiological and etiological variations in hepatocellular carcinoma
Evangelista Sagnelli1, Margherita Macera2, Antonio Russo2
1Section of Infectious Diseases, Department of Mental Health and Public Medicine, University of Campania Luigi Vanvitelli, Via L. Armanni 5, 80131, Naples, Italy. evangelista.sagnelli@unicampania.it.
Infection
|July 27, 2019
Summary
Hepatocellular carcinoma (HCC) is a major liver cancer. While HBV and HCV cases decline, NASH-related HCC rises, necessitating improved prevention and treatment strategies for global health.
Area of Science:
- Hepatology
- Oncology
- Public Health
Background:
- Hepatocellular carcinoma (HCC) is the most common liver cancer globally.
- Key risk factors include chronic liver disease (HBV, HCV), NAFLD, alcohol, aflatoxins, diabetes, and obesity.
Purpose of the Study:
- To analyze current trends in HCC epidemiology.
- To project future changes in HCC burden and identify key drivers.
Main Methods:
- Review of epidemiological data on HCC.
- Analysis of trends related to viral hepatitis, NAFLD, alcohol, and environmental factors.
Main Results:
- NASH-related HCC cases are increasing in Western countries.
- HBV/HCV-related HCC cases are declining due to vaccination and effective therapies.
- Global HCC burden is projected to rise due to population growth and aging.
Conclusions:
- Wider HBV vaccination and effective HBV/HCV treatment are crucial.
- Public health campaigns promoting healthy diets and reduced alcohol consumption are needed.
- Further research into HCC pathogenesis is vital for optimized prevention.
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