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Mesenchymal stem cells and IL-37: a powerful combination
A Gugliandolo1, A L Caraffa2, C E Gallenga3
1IRCCS Centro Neurolesi "Bonino Pulejo", Messina, Italy.
Abstract:
Mesenchymal stem cells (MSCs) are able to exert immunomodulatory and anti-inflammatory actions. Thanks to these properties, MSCs may be a promising alternative approach for the treatment of inflammatory disease. Important cytokines involved in inflammation are those included in the IL-1 family. Interleukin-37 (IL-37) is one of the member able to suppress both innate and adaptive immunity. Recently, it was found that MSCs and their derivatives can modulate IL-37, and MSCs expressing IL-37 seem to have an enhanced therapeutic efficacy.
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