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Related Experiment Video

Updated: Jan 21, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
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Infectious mononucleosis, active component, U.S. Armed Forces, 2002-2018.

Shauna Stahlman, Valerie F Williams, Saxia Ying

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    Infectious mononucleosis (IM) affected 23,780 service members from 2002-2018. Incidence was highest in young, non-Hispanic white recruits, though overall rates remained stable.

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    Area of Science:

    • Epidemiology
    • Infectious Diseases
    • Military Health

    Background:

    • Infectious mononucleosis (IM) is an acute illness with symptoms like fever and fatigue.
    • IM can significantly impact military readiness during its acute phase.

    Purpose of the Study:

    • To analyze incidence rates, trends, and demographic factors of IM in active component service members.
    • To understand the epidemiology of IM within a military population.

    Main Methods:

    • Retrospective analysis of incident IM cases among active component service members.
    • Surveillance period: 2002-2018.
    • Data included incidence rates, age, race/ethnicity, and enlistment status.

    Main Results:

    • Overall incidence rate was 104.2 cases per 100,000 person-years.
    • Highest incidence in youngest age groups, decreasing with age.
    • Markedly higher rates in non-Hispanic white service members compared to other groups.
    • Recruits had significantly higher IM incidence (364.9 per 100,000 p-yrs) than enlisted personnel and officers.
    • Incidence remained stable around 100 per 100,000 person-years throughout the study period.

    Conclusions:

    • IM incidence in the military is influenced by age, race/ethnicity, and enlistment status.
    • While not severe, IM impacts duty availability.
    • Findings highlight specific demographic groups at higher risk within the military.