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Updated: Jan 21, 2026
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The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
Published on: November 19, 2008
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Hyperbaric oxygen therapy in patients with hypoxic ischemic encephalopathy.
Ravi Sankaran1, Kurupath Radhakrishnan2, K R Sundaram3
1Department of Physical Medicine and Rehabilitation, Hyperbaric Medicine Division, Amrita Institute of Medical Sciences, Cochin, Kerala, India.
Neurology India
|July 27, 2019
Summary
Hyperbaric oxygen therapy (HBOT) shows promise for improving outcomes in hypoxic ischemic encephalopathy (HIE) patients. Early treatment within nine months post-injury may lead to better functional recovery and consciousness improvement.
Area of Science:
- Neurology
- Hyperbaric Medicine
- Neurorehabilitation
Background:
- Hypoxic ischemic encephalopathy (HIE) is a severe neurological condition.
- Limited effective treatments exist for long-term recovery.
- Hyperbaric oxygen therapy (HBOT) is being explored as a potential intervention.
Purpose of the Study:
- To evaluate the effectiveness of HBOT in patients diagnosed with HIE.
- To compare functional outcomes between HIE patients receiving HBOT and those who did not.
Main Methods:
- A non-randomized case-control observational study was conducted.
- Twenty-five HIE patients with a Coma Recovery Scale-Revised (CRS-R) score below 7 were included.
- Patients were grouped based on treatment timing (1-12 months post-injury) and received varying HBOT protocols (20 or 60 sessions at 2 ATA).
Main Results:
- Significant improvements in CRS-R scores were observed in the HBOT group at 1-3 and 4-8 months post-injury.
- A greater proportion of patients receiving HBOT demonstrated improvement in disorder of consciousness (DOC).
Conclusions:
- HBOT administered within the first nine months after HIE can enhance patient recovery.
- Early HBOT intervention may lead to improved functional outcomes in HIE patients.
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