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Design and Validation of a Volumetric-extrusion Bioprinter for Bioprinting of Soluble Basement Membrane Extract for Translational Research
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Organs by design: can bioprinting meet self-organization?
Ivan Martin1, Jos Malda2,3, Nicolas C Rivron4
1Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Current Opinion in Organ Transplantation
|July 27, 2019
Summary
Developing complex organs from stem cells is challenging. This review explores combining bioprinting and self-organization for engineered organs, advancing regenerative medicine and organogenesis research.
Area of Science:
- Biotechnology
- Regenerative Medicine
- Developmental Biology
Background:
- Organ transplantation faces a critical shortage of donor organs.
- Engineering functional organs from stem cells is a promising solution.
- Developing complex organ structures remains a significant challenge.
Purpose of the Study:
- To review current approaches in organ regeneration.
- To explore the synergy between bioprinting and self-organization.
- To advance the concept of organogenesis by design.
Main Methods:
- Review of bioprinting technologies for patterned cell deposition.
- Analysis of self-organization principles in organoid development.
- Discussion of synergistic strategies combining bioprinting and self-organization.
Main Results:
- Bioprinting offers structural control, while self-organization leverages developmental principles.
- Combining these approaches can enhance control and robustness in organ development.
- Synergistic strategies pave the way for 'organogenesis by design'.
Conclusions:
- Integrating bioprinting and self-organization offers a powerful paradigm for engineering complex organs.
- This combined approach has implications for generating transplantable organs.
- It also provides tools for studying organogenesis mechanisms and testing therapies.
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