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Cardiorespiratory responses to low-level ozone exposure: The inDoor Ozone Study in childrEn (DOSE)

Jing Huang1, Yi Song2, Mengtian Chu1

  • 1Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, China.

Environment International
|July 27, 2019
PubMed

Insights

Even low indoor ozone levels harm children's heart health, increasing heart rate and affecting autonomic function. This highlights the need for protective measures against indoor air pollution.

Area of Science:

  • Environmental Health
  • Pediatric Cardiology
  • Public Health

Background:

  • Indoor air pollution is a growing public health concern.
  • Limited evidence exists on indoor ozone's cardiorespiratory effects in children.
  • Underlying biological mechanisms remain unclear.

Purpose of the Study:

  • To assess cardiorespiratory responses to indoor ozone exposure in children.
  • To investigate the impact of low-level indoor ozone on pediatric cardiovascular health.
  • To explore potential mechanisms linking ozone exposure to adverse health outcomes in children.

Main Methods:

  • A repeated-measure study involving 46 middle-school children in Beijing.
  • Real-time monitoring of indoor ozone and co-pollutants (PM, BC) in classrooms.
  • Repeated cardiorespiratory health measurements including ECG, blood pressure, FeNO, and lung function.

Main Results:

  • Low-level indoor ozone exposure (mean 8.7 ppb) was associated with reduced cardiac autonomic function (SDNN) and increased heart rate (HR).
  • A 1-ppb increase in ozone correlated with a significant reduction in SDNN and an increase in HR.
  • Associations were stronger with higher black carbon levels; no significant effects on airway inflammation or lung function were observed.

Conclusions:

  • Low-level indoor ozone exposure negatively impacts children's cardiac autonomic function and heart rate.
  • These findings suggest a potential mechanism for ozone-induced cardiovascular effects in pediatric populations.
  • Increased protective measures are recommended to mitigate acute adverse effects of indoor ozone in children.
Abstract

Keywords:
Cardiorespiratory responsesChildrenIndoor exposureLow-level ozone

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