Related Experiment Video
Updated: Jan 21, 2026
07:41
Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
Published on: July 12, 2024
3.5K
Recent advances in microneedle composites for biomedical applications: Advanced drug delivery technologies
Sanjay Sharma1, Ketan Hatware1, Prashant Bhadane1
1NMIMS, School of Pharmacy and Technology Management, Shirpur, Maharashtra, India.
Summary
Microneedle drug delivery shows promise for treating chronic conditions and vaccines. Challenges remain in delivering hydrophilic drugs and large molecules, but fabrication techniques and clinical trials are advancing.
Area of Science:
- Biomedical Engineering
- Drug Delivery Systems
- Nanotechnology
Background:
- Microneedle technology is gaining traction for transdermal drug delivery.
- It offers potential for treating chronic diseases like osteoporosis, diabetes, and cancer.
- It also shows promise for vaccine delivery, including protein and DNA-based vaccines.
Purpose of the Study:
- To review the chronological development of microneedle fabrication techniques from 2000-2019.
- To summarize characterization, fabrication methods, biological applications, and challenges of microneedle drug delivery.
- To highlight relevant patents in the microneedle field.
Main Methods:
- Literature review of microneedle fabrication techniques and applications.
- Analysis of clinical trial data and regulatory perspectives.
- Patent search in the USPTO database for microneedle technology.
Main Results:
- Significant progress in controlled drug release using microneedles.
- Advancements in fabrication techniques and modifications for diverse applications.
- Identification of challenges, particularly in delivering hydrophilic drugs and macromolecules.
Conclusions:
- Microneedles are a promising platform for drug and vaccine delivery.
- Continued research in fabrication and formulation is needed to overcome delivery challenges.
- The field is supported by ongoing clinical trials and patent activity.
Related Concept Videos
00:56Extraction: Advanced Methods
1.1K
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.1K
02:22Overview of Advanced Functional Groups
29.2K
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
29.2K
01:08Sample Preparation for Analysis: Advanced Techniques
1.3K
Accurate analysis of complex samples often requires advanced preparation techniques to achieve reliable and reproducible results. Samples containing inorganic or organic materials can be challenging to dissolve or decompose effectively. Standard sample preparation methods include acid digestion, fusion, dry ashing, and wet digestion.
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
1.3K
01:30Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques
492
Airway management is essential in emergency and surgical medicine, ensuring ventilation and oxygenation in patients who cannot maintain their own airway. Clinicians use a range of techniques and devices to secure the airway, depending on the patient’s condition and the clinical context. Key methods include endotracheal intubation, rapid sequence intubation (RSI), supraglottic airway devices, and advanced visualization aids. In cases where these approaches fail, surgical airway...
492
01:16Drug Delivery: Overview
750
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
750
01:18Drug Delivery: Enteral Route
1.6K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.6K