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Preparation and Characterization of C60/Graphene Hybrid Nanostructures
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Preparation of graphene oxide-graphene quantum dots hybrid and its application in cancer theranostics

Mukesh Kumar Kumawat1, Mukeshchand Thakur1, Rohan Bahadur1

  • 1Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay (IIT Bombay), Mumbai, India.

Materials Science & Engineering. C, Materials for Biological Applications
|July 28, 2019
PubMed

Insights

This study introduces a new hybrid nanomaterial, graphene oxide and graphene quantum dots (GO-PEI-GQDs), for cancer theranostics. This composite shows enhanced imaging, photothermal therapy, and cytotoxicity in breast cancer cells.

Area of Science:

  • Nanomedicine
  • Materials Science
  • Biotechnology

Background:

  • Graphene oxide (GO) and graphene quantum dots (GQDs) are widely researched for cancer diagnostics and therapeutics.
  • Hybrid nanomaterials combining 2D GO and 0D GQDs for theranostics are underexplored.

Purpose of the Study:

  • To develop and characterize a novel GO-GQD hybrid nanomaterial for cancer theranostics.
  • To evaluate the diagnostic (cell imaging) and therapeutic (photothermal, oxidative stress) capabilities of the hybrid material in breast cancer cells.

Main Methods:

  • Fabrication of a stable GO-PEI-GQDs complex using electrostatic layer-by-layer assembly with a polyethylene imine bridge.
  • Comparative analysis of the hybrid material (GO-PEI-GQDs) against individual GO and GQDs.
  • Assessment of cell imaging, photothermal response, and oxidative stress induction in MDA-MB-231 breast cancer cells.

Main Results:

  • The GO-PEI-GQDs complex demonstrated stable fluorescence imaging capabilities.
  • An excellent photothermal response (44-49°C) was observed upon laser irradiation (808 nm, 0.5 W/cm², 5 min) at concentrations up to 50 μg/mL.
  • Synergistic effects were noted, including enhanced photothermal and cytotoxic activities compared to individual components.

Conclusions:

  • The GO-PEI-GQDs hybrid nanomaterial exhibits promising synergistic theranostic properties for cancer treatment.
  • This 2D-0D heterosystem offers improved performance for diagnostics and therapy, advancing cancer theranostics.
Keywords:
Graphene oxideGraphene quantum dotsPhotodynamic therapyPhotothermal

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