Preparation and Characterization of Perforated SERS Active Array for Particle Trapping and Sensitive Molecular Analysis
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Updated: Jan 21, 2026

Mass-Sensitive Particle Tracking to Characterize Membrane-Associated Macromolecule Dynamics
Published on: February 18, 2022
István Rigó1, Miklós Veres2, Tamás Váczi2
1Institute for Solid State Physics and Optics, Wigner Research Centre for Physics, Konkoly-Thege Miklós út 29-33., HAS, 1121 Budapest, Hungary. rigo.istvan@wigner.mta.hu.
Abstract:
A gold-coated array of flow-through inverse pyramids applicable as substrate for entrapment and immobilization of micro-objects and for surface enhanced Raman spectroscopic measurements was fabricated using bulk micromachining techniques from silicon. Surface morphology, optical reflectance, immobilization properties, and surface enhanced Raman amplification of the array were modelled and characterized. It was found that the special perforated periodic 3D structure can be used for parallel particle and cell trapping and highly sensitive molecular analysis of the immobilized objects.
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