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Bilateral tibial Brodie's abscess in a young patient treated with BAG-S53P4: case report
Andrea Cossio1, Jole Graci2,3, Antonino Salvatore Lombardo1
1Orthopedic Department, San Gerardo Hospital, University of Milano - Bicocca, Monza, Italy.
Insights
Bioactive glass BAG-S53P4 effectively treated Brodie's abscess in a pediatric tibia case. This bone substitute eradicated infection without impacting growth, showing promising results for children.
Area of Science:
- Pediatric Orthopedics
- Biomaterials Science
Background:
- Brodie's abscess is a chronic pyogenic osteomyelitis affecting children's long bones.
- Standard treatment involves antibiotics, sometimes with surgery.
Observation:
- A 12-year-old boy with a tibial Brodie's abscess near the growth plate received conservative treatment.
- Antibiotic therapy was interrupted due to intolerance.
Findings:
- Surgical treatment with bioactive glass BAG-S53P4 resulted in excellent outcomes.
- The infection was eradicated without adverse effects on growth or bone development.
Implications:
- Bioactive glass BAG-S53P4 is a safe and effective bone substitute for pediatric osteomyelitis.
- This material shows potential for treating bone infections while preserving growth plate function.
Background:
Brodie's abscess is a form of chronic pyogenic osteomyelitis that usually affects the cancellous part of the long bones in children. Its treatment is represented by antibiotic therapy alone or in association with surgical procedures.
Case Presentation:
A 12-years-old male affected by a Brodie's abscess of the tibia involving the distal growth plate was admitted to the Pediatric Department for a conservative treatment. After several attempts of antibiotic therapy interrupted for intolerance manifestations he was surgically treated with bioactive glass BAG-S53P4 (BonAlive, BonAlive Biomaterials Ltd., Biolinja, Finland), with excellent results.
Conclusions:
In our experience BAG-S53P4 has proven to be an effective bone substitute without side effects even in the pediatric population. In our case it eradicated the infection without interfere with the growth; neither epiphysiodesis nor other disorders were found during the follow-up. For the publication of this case report we followed the CARE guidelines for good clinical case reports; the parents gave consent for publication.