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Related Concept Videos

Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

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Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
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An Incident or Occurrence Report in a healthcare setting is a crucial document used to record any unexpected occurrence that may or may not have affected a patient, employee, or visitor. Such reports are critical to improving patient safety and include all details leading up to and including the event.
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Reporter Genes02:11

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Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
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Automated Measurement of Cryptococcal Species Polysaccharide Capsule and Cell Body
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Cryptococcal meningitis presenting as acute flaccid paralysis: A case report.

Vanessa Correa-Forero1, Gabriel D Pinilla-Monsalve2, Jaime A Valderrama-Chaparro3

  • 1Fundación Valle del Lili, Department of Internal Medicine, Cra. 98 No. 18-49, Cali, Colombia; Facultad de Ciencias de la Salud, Universidad Icesi, Calle 18 No. 122-135, Cali, Colombia.

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Summary

Cryptococcal meningitis, a fungal infection, can cause rare cases of acute flaccid paralysis and peripheral nerve issues, even in non-HIV patients. Early diagnosis and antifungal treatment are crucial for recovery.

Keywords:
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Area of Science:

  • Neurology
  • Infectious Diseases
  • Mycology

Background:

  • Cryptococcus is a fungus known for nervous system infections, particularly in immunocompromised individuals.
  • Neurological cryptococcosis typically presents as meningitis with headache, fever, and neck stiffness, often affecting the brain.

Observation:

  • A rare case of a non-HIV, diabetic patient presenting with acute flaccid paralysis and peripheral nerve involvement is described.
  • The patient exhibited symptoms including dysarthria, facial paralysis, ascending quadriparesis, hyporeflexia, and urinary retention.
  • Initial neuroimaging was inconclusive for vascular or demyelinating causes, and electrophysiological studies suggested acute flaccid paralysis of unknown origin.

Findings:

  • Cerebrospinal fluid analysis confirmed Cryptococcus neoformans var. gatti as the causative agent.
  • The patient received antifungal treatment with amphotericin B and fluconazole.
  • Significant improvement in polyneuroradiculopathy symptoms was observed during hospitalization.

Implications:

  • This case highlights that spinal cord and peripheral nerve involvement by Cryptococcus can manifest as acute flaccid paralysis.
  • Cryptococcal meningitis should be considered in the differential diagnosis of acute flaccid paralysis, even in HIV-negative individuals.
  • Prompt diagnosis and appropriate antifungal therapy are essential for managing this rare neurological complication.