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Calcium Administration During Weaning From Cardiopulmonary Bypass: A Narrative Literature Review

Vladimir V Lomivorotov1, Elizaveta A Leonova2, Alessandro Belletti3

  • 1Department of Anaesthesiology and Intensive Care, E. Meshalkin National Medical Research Center, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia.

Journal of Cardiothoracic and Vascular Anesthesia
|July 28, 2019
PubMed

Insights

Intravenous calcium may offer transient cardiovascular benefits during cardiopulmonary bypass weaning but carries risks. Further research is needed to determine its overall impact on patient outcomes.

Area of Science:

  • Cardiology
  • Critical Care Medicine
  • Pharmacology

Background:

  • Managing patients during weaning from cardiopulmonary bypass requires safe and effective strategies.
  • Intravenous calcium is sometimes used as an initial treatment option.
  • Calcium's physiological role suggests potential cardiovascular support during this critical phase.

Purpose of the Study:

  • To evaluate the role and effects of intravenous calcium administration in patients undergoing weaning from cardiopulmonary bypass.
  • To assess the potential benefits and risks associated with calcium use in this patient population.

Main Methods:

  • Review of physiological roles of calcium in cardiovascular function.
  • Analysis of reported transient effects of calcium administration.
  • Consideration of potential adverse events and limitations.

Main Results:

  • Mild hypocalcemia post-cardiopulmonary bypass does not significantly impair cardiovascular function.
  • Calcium administration may transiently improve hemodynamic parameters like blood pressure and cardiac index.
  • Potential adverse effects include reduced graft flow, blunted response to beta-agonists, and organ injury.

Conclusions:

  • While calcium may offer short-term hemodynamic advantages, its impact on significant clinical outcomes remains unknown.
  • Potential side effects may restrict the use of calcium salts.
  • Further studies are essential to fully understand the effects of calcium on patient outcomes.

Keywords:
calciumhypocalcemiainotropesvasopressorsweaning from cardiopulmonary bypass

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