Related Experiment Video

Updated: Jan 21, 2026

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
06:39

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Published on: April 13, 2015

15.6K

Endothelial Microvesicles Circulating in Peripheral and Coronary Circulation Are Associated With Central Blood

Eugenia Gkaliagkousi1, Eleni Gavriilaki1, Ioannis Vasileiadis2

  • 13rd Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

American Journal of Hypertension
|July 28, 2019
PubMed

Insights

Endothelial microvesicles (EMVs) are elevated in acute coronary syndrome (ACS) and coronary artery disease (CAD). These markers indicate vascular damage in both peripheral and coronary circulation, especially in ACS patients.

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Endothelial Biology

Background:

  • Endothelial microvesicles (EMVs) are recognized indicators of endothelial injury.
  • Limited data exists on EMV levels in acute coronary syndrome (ACS) and stable coronary artery disease (CAD) patients' coronary circulation.
  • The study investigates EMVs as potential markers in ACS and CAD.

Purpose of the Study:

  • To compare EMV levels in peripheral and coronary circulation between ACS, stable CAD, and control groups.
  • To explore the association between EMVs and markers of preclinical target organ damage.
  • To determine if EMVs reflect ongoing vascular damage in ACS and CAD.

Main Methods:

  • Consecutive patients undergoing coronary angiography were enrolled.
  • Blood samples were collected from the left coronary artery and femoral artery.
  • EMVs were quantified using flow cytometry; central systolic blood pressure (cSBP) was invasively measured.

Main Results:

  • Coronary artery disease (CAD) patients showed higher EMV levels than controls.
  • Acute coronary syndrome (ACS) patients had significantly elevated EMVs in both coronary and peripheral circulation compared to stable CAD.
  • Both ACS and CAD patients displayed higher EMVs in coronary versus peripheral circulation and an association with cSBP.

Conclusions:

  • EMVs serve as novel indicators of active vascular damage.
  • Elevated EMVs contribute to the inflammatory and thrombotic cycle in ACS and stable CAD.
  • EMVs may play a role in the pathophysiology of coronary artery disease.
Abstract

Keywords:
acute coronary syndromeblood pressurecoronary artery diseaseendothelialhypertensionmicrovesicles

More Related Videos

Isolation of Mouse Coronary Endothelial Cells07:36

Isolation of Mouse Coronary Endothelial Cells

Published on: July 3, 2016

11.9K
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.8K

Related Concept Videos

Coronary Circulation01:21

Coronary Circulation

The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
6.7K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
909
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
387
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
220
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
340
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
601