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Diagnosis and treatment of Hymenoptera venom allergy: S2k Guideline of the German Society of Allergology and Clinical Immunology (DGAKI) in collaboration with the Arbeitsgemeinschaft für Berufs- und Umweltdermatologie e.V. (ABD), the Medical Association of German Allergologists (AeDA), the German Society of Dermatology (DDG), the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNOKC), the German Society of Pediatrics and Adolescent Medicine (DGKJ), the Society for Pediatric Allergy and Environmental Medicine (GPA), German Respiratory Society (DGP), and the Austrian Society for Allergy and Immunology (ÖGAI).

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Related Experiment Video

Updated: Jan 21, 2026

Basophil Activation Test for Allergy Diagnosis
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[Hymenoptera venom allergy].

Wolfgang Sieber1, Monika Brunner1

  • 1Abteilung für Pneumologie und Allergologie, Kreisklinik Wörth an der Donau.

Deutsche Medizinische Wochenschrift (1946)
|July 28, 2019
PubMed
Summary
This summary is machine-generated.

Allergic reactions to honeybee and wasp stings are common and can cause severe anaphylaxis. Specific immunotherapy offers a highly successful treatment, with nearly 100% effectiveness in preventing future reactions.

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Area of Science:

  • Allergy and Immunology
  • Toxicology

Background:

  • Hymenoptera venom allergies, particularly from honeybees and wasps, affect up to 3.5% of the population.
  • Reactions are typically IgE-mediated Type I hypersensitivity.
  • Established diagnostic methods include patient history, skin tests, and specific IgE antibody detection.

Purpose of the Study:

  • To review the efficacy of specific immunotherapy for Hymenoptera venom allergies.
  • To outline current therapeutic protocols and diagnostic approaches.
  • To highlight the impact of successful treatment on patients' quality of life.

Main Methods:

  • Review of established diagnostic tools: medical history, skin prick tests, and specific IgE antibody assays.
  • Discussion of specific immunotherapy protocols, including standard maintenance doses (100-200mg).
  • Emphasis on sting challenge tests for verifying treatment efficacy.

Main Results:

  • Specific immunotherapy demonstrates nearly 100% success rates in hyposensitization.
  • A maintenance dose of 100mg is often sufficient, with potential increases to 200mg in some cases.
  • Treatment duration typically ranges from 3-5 years, after which it can be discontinued.

Conclusions:

  • Specific immunotherapy is a highly successful and recommended therapy for honeybee and wasp sting allergies.
  • Effective immunotherapy significantly improves patients' quality of life and reduces the severity of sting reactions.
  • Diagnostic accuracy is enhanced by recombinant antibodies in specific clinical situations.