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Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
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The correlation between microRNAs and Helicobacter pylori in gastric cancer

Narges Dastmalchi1, Reza Safaralizadeh1, Seyed Mahdi Banan Khojasteh1

  • 1Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.

Pathogens and Disease
|July 28, 2019
PubMed

Insights

Helicobacter pylori infection promotes gastric cancer by altering microRNAs (miRNAs). This review explores how H. pylori pathogenesis affects miRNA regulation and their role in gastrointestinal diseases.

Area of Science:

  • Gastroenterology
  • Molecular Biology
  • Oncology

Background:

  • Helicobacter pylori infection is a primary driver of gastric inflammation and gastric cancer (GC).
  • MicroRNAs (miRNAs) are emerging as key regulators in H. pylori pathogenesis and associated diseases.
  • Understanding the interplay between H. pylori and miRNAs is crucial for GC research.

Purpose of the Study:

  • To review the correlation between miRNAs and H. pylori in gastrointestinal diseases.
  • To highlight the role of H. pylori and its virulence factors in miRNA deregulation.
  • To explore the molecular pathways and targets involved in this interaction.

Main Methods:

  • Literature review of studies investigating H. pylori and miRNA interactions.
  • Analysis of research focusing on H. pylori's impact on miRNA regulatory networks.
  • Examination of studies detailing altered miRNA expression in H. pylori-related diseases.

Main Results:

  • H. pylori infection significantly impacts miRNA expression levels.
  • Virulence factors of H. pylori contribute to the deregulation of specific miRNAs, including oncogenic miRs.
  • Various molecular pathways and miRNA targets are implicated in the H. pylori-miRNA axis.

Conclusions:

  • miRNAs play a critical regulatory role in H. pylori pathogenesis and H. pylori-related gastric cancer.
  • The interaction between H. pylori and miRNAs involves complex molecular mechanisms and pathways.
  • Further research into the H. pylori-miRNA connection may reveal novel therapeutic strategies for gastric cancer.
Keywords:
Helicobacter pylorigastric cancergastric diseasesmiRNA

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