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Updated: Jan 21, 2026

Inducement and Evaluation of a Murine Model of Experimental Myopia
Published on: January 22, 2019
Morphological Characteristics and Risk Factors of Myopic Maculopathy in an Older High Myopia Population-Based on the
Qiuying Chen1, Jiangnan He1, Guangyi Hu1
1Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai, China.
Purpose:
To investigate the characteristics, mergers, and risk factors of different types of myopic maculopathy (MM) in a highly myopic population.
Design:
Population-based, cross-sectional study.
Methods:
A total of 1086 eyes (762 patients) were enrolled. Each participant underwent detailed ocular examinations. Combining the fundus photographs and optical coherence tomography images, types of MM were assessed as myopic atrophy maculopathy (MAM), myopic tractional maculopathy (MTM), or myopic neovascular maculopathy (MNM) according to the ATN classification system. Peripapillary atrophy (PPA) area, tilt ratio, and macular choroidal thickness (mChT) were measured individually.
Results:
Eyes with larger PPA area were more likely to have MAM (odds ratio [OR], 1.220; P = .037 per 1-mm2 increase) and MNM (OR, 1.723; P < .001 per 1-mm2 increase), and eyes with thicker mChT were less likely to have MAM (OR, 0.740; P < .001 per 10-μm increase) and MNM (OR, 0.784; P < .001 per 10-μm increase), whereas eyes with higher tilt ratio were less likely to have MTM (OR, 0.020; P < .001 per 1 increase). The severity of MTM and MNM was not precisely consistent with that of MAM.
Conclusions:
Different types of MM have different risk factors; larger PPA area and thinner mChT are risk factors for MAM and MNM, whereas lower tilt ratio is a risk factor for MTM. Our results indicate that the pathogenesis of MTM is different from that of MAM and MNM, and a tractional component should be considered as a possible component to the myopic macular classification.
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