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Two new alkaloids isolated from traditional Chinese medicine Binglang the fruit of Areca catechu
Mengru Cao1, Hanwen Yuan1, Muhammad Daniyal1
1TCM and Ethnomedicine Innovation & Development International Laboratory, Academician Atta-ur-Rahamn Belt and Road Traditional Medicine Research Center, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, PR China.
Abstract:
Binglang, the fruit of Areca catechu L, has a long history as an important Chinese herbal medicine. Two new alkaloids (1 and 2), along with forty-one known compounds (3-43) were isolated from the dried fruit of Areca catechu L. The structures were elucidated on basis of the IR, UV, MS and 1D, 2D NMR spectroscopic data. Compounds 26 and 33 showed weak cytotoxicity against human gastric cancer cell line (BGC-823) with IC50 of 15.91 μM and 20.13 μM, respectively.
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