Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

7.2K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.2K
Notch Signaling Pathway03:14

Notch Signaling Pathway

6.5K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.5K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

9.9K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
9.9K
Insulin: The Receptor and Signaling Pathways01:28

Insulin: The Receptor and Signaling Pathways

2.8K
Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
2.8K
IP3/DAG Signaling Pathway01:11

IP3/DAG Signaling Pathway

14.3K
Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and...
14.3K
Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

6.2K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimization of elastin proportion and crosslinking for collagen-elastin scaffolds as skin substitutes.

International journal of biological macromolecules·2026
Same author

Choroidal measurements in patients affected by PXE-related retinopathy.

Frontiers in ophthalmology·2025
Same author

Potential of Heparan Sulphate Mimetics Integrated Into Collagen Scaffolds for Enhanced Skin Wound Healing.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society·2025
Same author

Comparative in vitro evaluation of elastogenic compounds for pharmacological modulation of extracellular matrix production in human dermal fibroblasts.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2025
Same author

Chondroitin sulfate and hyaluronan in the vitreous of patients with rhegmatogenous retinal detachment.

Experimental eye research·2025
Same author

Calcification of the elastic component: the impact on the cardiovascular system.

Frontiers in cardiovascular medicine·2025
Same journal

Targeting lipoprotein lipase-positive macrophage-driven GDF-15 expression alleviates cancer Cachexia in obese head and neck squamous cell carcinoma.

Cellular signalling·2026
Same journal

BRD8 promotes non-small cell lung cancer progression by stabilizing MBD2 and activating the MAPK pathway.

Cellular signalling·2026
Same journal

Hypoxia remodels circSTX6 nuclear export through URH49-ALYREF to drive IGF1-mediated bladder cancer progression.

Cellular signalling·2026
Same journal

Integrative spatiotemporal analysis uncovers an Fto-mediated epigenetic-metabolic axis governing myocardial ischemic injury.

Cellular signalling·2026
Same journal

Caspase-3 activation is a brake in GSDMD-mediated pyroptosis.

Cellular signalling·2026
Same journal

ILF3 promotes proliferation and invasion of hepatocellular carcinoma cells through STAT3 phosphorylation and formation of an endogenous complex with SRPK1.

Cellular signalling·2026
See all related articles

Related Experiment Video

Updated: Jan 21, 2026

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue
06:36

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue

Published on: May 1, 2019

7.4K

Signaling pathways in elastic tissues.

Willeke F Daamen1, Daniela Quaglino2

  • 1Radboud university medical center, Radboud Institute for Molecular Life Sciences, Department of Biochemistry, Nijmegen, The Netherlands.

Cellular Signalling
|July 28, 2019
PubMed
Summary
This summary is machine-generated.

Elastin, once thought only for elasticity, is now known to release signaling molecules and be a target of pathways like TGF-β/BMP. Understanding these networks aids disease therapies and biomaterial development.

More Related Videos

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

7.9K
Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

20.7K

Related Experiment Videos

Last Updated: Jan 21, 2026

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue
06:36

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue

Published on: May 1, 2019

7.4K
Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

7.9K
Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

20.7K

Area of Science:

  • Biochemistry
  • Cell Biology
  • Tissue Engineering

Background:

  • Elastin traditionally viewed as a structural matrix component for tissue elasticity.
  • Emerging research highlights elastic fibers' roles beyond structure, involving signaling.
  • Connective tissue homeostasis is regulated by complex cellular interactions.

Purpose of the Study:

  • To explore the multifaceted roles of elastin in connective tissue homeostasis.
  • To investigate elastin's involvement in signaling pathways, particularly TGF-β/BMP axis.
  • To identify potential therapeutic targets and biomaterial applications based on elastin's regulatory functions.

Main Methods:

  • Review of current literature on elastin structure and function.
  • Analysis of signaling pathways involving elastin and the TGF-β/BMP axis.
  • Exploration of implications for disease pathology and regenerative medicine.

Main Results:

  • Elastic fibers are not only structural but also sources of bioactive peptides (elastokines).
  • Elastin is a target and modulator of key signaling pathways, including TGF-β/BMP.
  • These interactions are crucial for maintaining connective tissue homeostasis.

Conclusions:

  • Elastin's role extends beyond passive elasticity to active signaling regulation.
  • Understanding elastin-mediated signaling networks offers therapeutic avenues for genetic and acquired diseases.
  • Functionalized biomaterials incorporating elastin could leverage these signaling properties.