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Updated: Jan 21, 2026

Profiling Ubiquitin and Ubiquitin-like Dependent Post-translational Modifications and Identification of Significant Alterations
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Actionable molecular alterations in advanced gynaecologic malignancies: updated results from the ProfiLER programme

Romain Varnier1, Olivia Le Saux2, Sylvie Chabaud3

  • 1Medical Practices Evaluation Team - HESPER EA7425, Centre Léon Bérard, Lyon, France; Université Claude Bernard Lyon 1, Lyon, France.

European Journal of Cancer (Oxford, England : 1990)
|July 28, 2019
PubMed
Summary

Molecular profiling identified actionable genomic alterations in 42.4% of advanced gynecologic cancer patients. However, only 12.6% received recommended targeted treatment, with 46% showing clinical benefit.

Keywords:
Gynaecologic cancerMolecular targeted agentsNext-generation sequencingPrecision medicineaCGH

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