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The 5-hydrazino-3-methylisothiazole-4-carboxylic acid, its new 5-substituted derivatives and their antiproliferative

Izabela Jęśkowiak1, Marcin Mączyński1, Justyna Trynda2

  • 1Department of Organic Chemistry, Faculty of Pharmacy, Wrocław Medical University, Wrocław, Poland.

Bioorganic Chemistry
|July 28, 2019
PubMed

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Nucleophilic acyl substitution is an important class of substitution reactions involving a nucleophile and an acyl compound, such as carboxylic acids and their derivatives. In these reactions, the leaving group attached to the acyl group is substituted by a nucleophile. The general mechanism proceeds via two steps.
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Carboxylic acid derivatives are formed by replacing the hydroxyl group of carboxylic acids with a different functional group. The most common carboxylic acid derivatives are:
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