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Updated: Jan 21, 2026

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
Published on: May 24, 2017
Initial e-cigarette flavoring and nicotine exposure and e-cigarette uptake among adolescents
Janet Audrain-McGovern1, Daniel Rodriguez2, Stephen Pianin1
1Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, USA.
Flavored e-cigarettes and those with nicotine increase adolescent use. Initial exposure to flavors predicts progression and escalation in e-cigarette use, highlighting risks for youth.
Area of Science:
- Adolescent Health
- Tobacco Control
- Public Health
Background:
- Electronic cigarettes (e-cigarettes) are the most prevalent tobacco product among adolescents.
- Understanding factors influencing adolescent e-cigarette initiation and sustained use is critical for public health interventions.
Purpose of the Study:
- To determine if initial exposure to flavored or nicotine-containing e-cigarettes predicts progression to current use and escalation of use among adolescents.
- To assess the impact of flavoring and nicotine presence on the trajectory of e-cigarette use in a high school population.
Main Methods:
- A longitudinal study involving 354 adolescents who had previously used e-cigarettes.
- Data collected via in-classroom surveys at baseline (9th grade) and every 6 months for 18 months.
- Latent Growth Curve Modeling was used to analyze the association between initial exposure characteristics and subsequent use patterns.
Main Results:
- Initial use of flavored e-cigarettes was significantly associated with progression to current use (p=0.04) and increased frequency of use (p=0.01).
- Initial use of e-cigarettes containing nicotine was linked to a greater number of days of use at baseline (p=0.03).
Conclusions:
- Flavoring and nicotine in e-cigarettes pose significant risks for continued and escalated use among adolescents.
- Regulations targeting e-cigarette flavors and nicotine content could effectively reduce adolescent e-cigarette use prevalence and intensity.
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