Related Experiment Video
Updated: Jan 21, 2026
07:09
A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
Published on: February 18, 2022
2.3K
Surgical Approaches in Heart Failure.
Candice Falls1, Andrew R Kolodziej2
1Internal Medicine-Cardiology, University of Kentucky, 1000 South Limestone Pavilion A 08.176, Lexington, KY, USA.
Critical Care Nursing Clinics of North America
|July 29, 2019
Summary
Advanced heart failure treatment is evolving. Mechanical circulatory support offers a vital alternative to heart transplant, serving as a bridge to transplant or destination therapy for patients with end-stage heart failure.
Area of Science:
- Cardiology and Cardiovascular Surgery
- Medical Device Technology
Background:
- Heart failure incidence and prevalence are rising globally, posing significant public health challenges.
- Despite advances in pharmacologic treatments, advanced heart failure continues to be associated with high morbidity and mortality rates.
- The persistent shortage of donor hearts limits the widespread application of heart transplantation.
Purpose of the Study:
- To explore advanced treatment options for patients with progressive heart failure.
- To evaluate the role of mechanical circulatory support (MCS) in managing advanced heart failure.
- To discuss the application of MCS as a bridge to heart transplantation and as destination therapy.
Main Methods:
- Review of current literature on heart failure management strategies.
- Analysis of the clinical outcomes and indications for mechanical circulatory support devices.
- Comparison of heart transplantation with mechanical circulatory support in advanced heart failure.
Main Results:
- Mechanical circulatory support is increasingly accepted as a viable treatment modality for advanced heart failure.
- MCS devices can effectively improve outcomes for patients ineligible for or awaiting heart transplantation.
- The use of MCS as destination therapy provides a long-term solution for select patient populations.
Conclusions:
- Mechanical circulatory support represents a critical advancement in the management of advanced heart failure.
- MCS offers a valuable therapeutic option, addressing the limitations of donor organ availability.
- Further research and technological innovation in MCS are essential to optimize patient care and outcomes.
Related Concept Videos
01:29Heart Failure II: Pathophysiology
783
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
783
01:17Pathophysiology of Heart Failure
3.0K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
3.0K
01:27Heart Failure I: Introduction
723
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
723
01:22Heart Failure VI: Adjunct Therapies
277
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
277
01:22Heart Failure Drugs: Diuretics
824
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
824
01:30Heart Failure V: Medical Management
227
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
227