Related Experiment Video
Updated: Jan 21, 2026
08:28
Expansion and Adipogenesis Induction of Adipocyte Progenitors from Perivascular Adipose Tissue Isolated by Magnetic Activated Cell Sorting
Published on: June 30, 2017
9.7K
Adipocyte-progenitor cell communication that influences adipogenesis
William Lloyd Haylett1, William Frank Ferris2
1Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Cellular and Molecular Life Sciences : CMLS
|July 29, 2019
Summary
Mature fat cells communicate with stem cells to influence fat distribution. Understanding this crosstalk in adipose tissue depots may reveal new insights into obesity and metabolic disease.
Area of Science:
- Endocrinology
- Cell Biology
- Metabolic Health
Background:
- Adipose tissue depots differ in their association with metabolic disease risk, with visceral fat being most detrimental.
- Regulation of adipose depot expansion, including adipocyte hypertrophy and hyperplasia, is not fully understood.
- Mature adipocytes secrete factors influencing adipose-derived stem cells (ADSCs) proliferation and differentiation.
Purpose of the Study:
- To review evidence on paracrine and endocrine crosstalk between mature adipocytes and ADSCs.
- To explore how this crosstalk affects adipogenesis and fat distribution.
- To highlight the potential impact on obesity and related comorbidities.
Main Methods:
- Literature review of in vitro and in vivo studies.
- Analysis of research on extracellular signaling mechanisms in adipose tissue.
- Synthesis of evidence on cell-to-cell communication within and between adipose depots.
Main Results:
- Evidence suggests mature adipocytes secrete signaling molecules that modulate ADSC behavior.
- This intercellular communication likely influences adipogenesis and fat distribution.
- Differential signaling between depots may contribute to metabolic complications.
Conclusions:
- Crosstalk between adipocytes and ADSCs is a key regulator of adipose tissue expansion and fat distribution.
- Understanding these endocrine and paracrine interactions is crucial for addressing obesity and metabolic disorders.
- Targeting these signaling pathways could offer novel therapeutic strategies.
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