Related Experiment Video

Updated: Jan 21, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

18.4K

The association between cumulative C-reactive protein and brachial-ankle pulse wave velocity

Lixia Sun1, Chunhong Ning2, Jiqiang Liu3

  • 1Department of Emergency, Affiliated Hospital, North China University of Science and Technology, No. 73 Jianshe South Road, Lubei District, Tangshan, 063000, China. drlixiasun@sina.com.

Aging Clinical and Experimental Research
|July 29, 2019
PubMed

Insights

Elevated cumulative C-reactive protein (cumCRP) is linked to greater arterial stiffness. This finding highlights the role of chronic inflammation in cardiovascular health, specifically in the development of stiff arteries.

Area of Science:

  • Cardiovascular Medicine
  • Inflammation Research
  • Public Health

Background:

  • Arterial stiffness is a key indicator of cardiovascular risk.
  • Chronic inflammation, indicated by C-reactive protein (CRP), may contribute to arterial stiffening.
  • Understanding the long-term effects of CRP on vascular health is crucial.

Purpose of the Study:

  • To investigate the association between cumulative C-reactive protein (cumCRP) and arterial stiffness.
  • To quantify the risk of arterial stiffness based on different levels of cumCRP exposure.

Main Methods:

  • A cross-sectional study of 15,432 participants from the Kailuan Cohort.
  • Participants categorized into four groups based on cumCRP quartiles.
  • Brachial-ankle pulse wave velocity (baPWV) and arterial stiffness rates analyzed using multiple logistic regression.

Main Results:

  • Average baPWV and the rate of arterial stiffness significantly increased across cumCRP quartiles (P < 0.001).
  • The highest cumCRP quartile showed a 42% increased risk of arterial stiffness compared to the lowest (adjusted OR 1.42).
  • Each 1 SD increase in cumCRP was associated with a 10% increase in arterial stiffness risk (adjusted OR 1.10).

Conclusions:

  • Higher cumulative C-reactive protein exposure is significantly associated with increased arterial stiffness.
  • Chronic inflammation plays a role in the development and progression of arterial stiffness.
  • Findings suggest cumCRP as a potential biomarker for cardiovascular risk assessment.
Abstract

Keywords:
Arterial stiffnessBrachial–ankle pulse wave velocityCumulative C-reactive protein

More Related Videos

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging06:08

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging

Published on: February 7, 2014

17.7K
Ultrasound-based Pulse Wave Velocity Evaluation in Mice08:07

Ultrasound-based Pulse Wave Velocity Evaluation in Mice

Published on: February 14, 2017

14.5K

Related Concept Videos

Velocity and Acceleration of a Wave00:51

Velocity and Acceleration of a Wave

A wave propagates through a medium with a constant speed, known as a wave velocity. It is different from the speed of the particles of the medium, which is not constant. In addition, the velocity of the medium is perpendicular to the velocity of the wave. The variable speed of the particles of the medium implies that there must be acceleration associated with it. 
The velocity of the particles can be obtained by taking the partial derivative of the position equation with respect to time....
4.8K
Cumulative Frequency Distribution01:04

Cumulative Frequency Distribution

A cumulative frequency distribution is another type of frequency distribution. Instead of reporting how many data values fall in some classes, it reports how many data values are contained in either that class or any class to its left. Technically, it means the sum of frequencies of the class and all the classes below it in a frequency distribution. A cumulative frequency is calculated by adding the frequency of each class lower than the corresponding class interval or category. In general, a...
8.1K
Ankle Joint01:10

Ankle Joint

The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
2.8K
The Wave Nature of Light02:12

The Wave Nature of Light

The nature of light has been a subject of inquiry since antiquity. In the seventeenth century, Isaac Newton performed experiments with lenses and prisms and was able to demonstrate that white light consists of the individual colors of the rainbow combined together. Newton explained his optics findings in terms of a "corpuscular" view of light, in which light was composed of streams of extremely tiny particles traveling at high speeds according to Newton's laws of motion.
60.9K
Pulse01:16

Pulse

When the heart pumps blood out, arterial elastic fibers play a crucial role in sustaining a high-pressure gradient. They expand to accommodate the received blood and then recoil - a process known as the pulse that can be either manually palpated or electronically quantified. Despite a reduction in its effect with increased distance from the heart, elements of the pulse's systolic and diastolic components persist, observable even at the arteriole level.
The pulse serves as a clinical...
2.0K
Pulse01:05

Pulse

The pulse is one of the most fundamental physiological indicators of the body's cardiovascular health. It is the rhythmic expansion and contraction of the arterial walls in response to the pressure generated by the heart's pumping action.
Pulse Rate and its Significance
Pulse rate, often measured in beats per minute (bpm), reflects the heart rate (HR), which is influenced by numerous factors such as stress, physical activity, and hormonal changes. A normal resting adult pulse rate falls...
3.5K