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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
926
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Updated: Jan 21, 2026

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
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Stem cell-based therapy for inflammatory bowel disease.

Hiromichi Shimizu1,2, Kohei Suzuki1,2, Mamoru Watanabe3

  • 1Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.

Intestinal Research
|July 30, 2019
PubMed
Summary
This summary is machine-generated.

Inflammatory bowel disease (IBD) treatments face challenges, with some patients unresponsive to current therapies. This review explores stem cell therapy for IBD, proposing intestinal stem cell transplantation using organoid culture as a novel approach.

Keywords:
Hematopoietic stem cellIntestinal stem cellMesenchymal stem cellMucosal healingOrganoids

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Area of Science:

  • Gastroenterology and Regenerative Medicine

Background:

  • Inflammatory bowel disease (IBD) involves gastrointestinal inflammation and mucosal damage.
  • Many patients remain refractory to conventional and biologic immunomodulating therapies, hindering mucosal healing.
  • Current stem cell therapies for IBD, including hematopoietic and mesenchymal stem cells, show controversial efficacy.

Purpose of the Study:

  • To review clinical challenges associated with stem cell-based therapies for IBD.
  • To introduce a novel therapeutic strategy involving intestinal stem cell transplantation for IBD treatment.

Main Methods:

  • Review of existing clinical studies on stem cell transplantation in IBD.
  • Development of an ex vivo intestinal organoid culture technique for intestinal stem cell transplantation.

Main Results:

  • Existing stem cell therapies for IBD have yielded controversial results.
  • A new method for ex vivo intestinal organoid culture has been established.

Conclusions:

  • There is a need for improved therapeutic strategies for refractory IBD.
  • Intestinal stem cell transplantation, utilizing ex vivo organoid culture, presents a promising new avenue for IBD treatment.