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T Cells Capture Bacteria by Transinfection from Dendritic Cells

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Published on: January 13, 2016

Histiocytic and Dendritic Cell Neoplasms.

Zenggang Pan¹, Mina L Xu²

¹Department of Pathology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06510-3218, USA.

Surgical Pathology Clinics

|July 30, 2019

Summary

Histiocytic and dendritic cell neoplasms are rare. Understanding their characteristics and molecular findings, like RAS-RAF-MEK-ERK pathway mutations, is key for accurate diagnosis and treatment.

Keywords:

Disseminated juvenile xanthogranuloma Erdheim-Chester disease Follicular dendritic cell sarcoma Histiocytic sarcoma Indeterminate dendritic cell tumor Interdigitating dendritic cell sarcoma Langerhans cell histiocytosis

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Area of Science:

Hematology
Oncology
Pathology

Background:

Histiocytic and dendritic cell neoplasms are rare hematologic disorders.
These neoplasms share characteristics with mature histiocytic/dendritic cells.
They can arise independently or alongside other neoplasms.

Purpose of the Study:

To review the clinicopathologic features of histiocytic and dendritic cell neoplasms.
To discuss differential diagnoses and diagnostic challenges.
To highlight the impact of recent molecular discoveries on these rare entities.

Main Methods:

Review of existing literature on histiocytic and dendritic cell neoplasms.
Analysis of morphologic, immunophenotypic, and ultrastructural findings.
Integration of recent molecular data, including RAS-RAF-MEK-ERK pathway mutations.

Main Results:

Histiocytic and dendritic cell neoplasms exhibit diverse presentations.
Distinguishing these neoplasms from each other and other conditions can be challenging.
Mutations in the RAS-RAF-MEK-ERK pathway are crucial for diagnosis and treatment.

Conclusions:

Accurate diagnosis requires understanding clinicopathologic features and differential diagnoses.
Molecular findings significantly improve diagnostic and therapeutic strategies.
Further research is needed to fully elucidate these rare neoplasms.