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Updated: Jan 21, 2026

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
Published on: June 14, 2015
[Anaphylaxis Induced by Fibrin Glue During Surgery for Pneumothorax]
Hiromichi Inoue1, Toshimasa Okazaki, Muneo Minowa
1Department of Thoracic Surgery, Ohta General Hospital Ohta Nishinouchi Hospital, Koriyama, Japan.
Abstract:
We report here our experience with a case of anaphylactic shock caused by fibrin glue. A 51-year-old male underwent a thoracoscopic surgery for refractory pneumothorax under local anesthesia. Bullae were revealed, and subsequently covered with fibrin glue and a polyglycolic acid sheet. Twenty-minutes after application of the fibrin glue, sudden drop of blood pressure less than 80 mmHg and a skin rash appeared. Since the patient was not administered any other drugs prior to the reduction in blood pressure, anaphylactic shock was considered to be caused by fibrin glue. The patient recovered after the treatment by dopamine and steroid.
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