Related Experiment Video

Updated: Jan 21, 2026

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay
07:44

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Published on: March 12, 2018

10.6K

Exploring the best treatment options for BRAF-mutant metastatic colon cancer

Julien Taieb1,2, Alexandra Lapeyre-Prost3, Pierre Laurent Puig4,5

  • 1Sorbonne Paris-Cité, Paris Descartes University, Assistance Publique Hôpitaux de Paris (APHP), Gastro-enterology and GI Oncology Department, Georges Pompidou European Hospital, Paris, France. jtaieb75@gmail.com.

British Journal of Cancer
|July 30, 2019
PubMed

Insights

The BRAFV600E mutation negatively impacts metastatic colorectal cancer (mCRC) prognosis. Current treatments for BRAF-mutant mCRC are suboptimal, necessitating novel therapeutic strategies for improved patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • The BRAFV600E mutation is a significant negative prognostic factor in metastatic colorectal cancer (mCRC).
  • This mutation drives Ras-independent MAPK pathway activation, promoting tumor growth and survival.
  • Current treatment strategies for BRAF-mutant mCRC are suboptimal, with limited efficacy.

Purpose of the Study:

  • To review emerging therapeutic strategies for BRAF-mutant mCRC.
  • To address the unmet needs in treating this patient population.
  • To explore the potential of novel combinations and immunotherapy.

Main Methods:

  • Literature review of current and emerging treatments for BRAF-mutant mCRC.
  • Analysis of prognostic and predictive roles of BRAF mutations.
  • Evaluation of treatment guidelines and clinical evidence.

Main Results:

  • BRAFV600E mutation confers poor prognosis in mCRC, confounding treatment efficacy analysis.
  • No single treatment regimen is definitively superior; triplet chemotherapy with bevacizumab is a common standard.
  • Emerging strategies include combination therapies with biologics, targeted agents, and immunotherapy.

Conclusions:

  • Patients with BRAF-mutant mCRC face unmet therapeutic needs.
  • Renewed research interest offers cautious optimism for improved clinical strategies.
  • Novel combinations and immunotherapy show promise for combating BRAF-mt mCRC.

More Related Videos

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose13:04

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose

Published on: October 14, 2015

13.9K
Methods for Culturing Human Femur Tissue Explants to Study Breast Cancer Cell Colonization of the Metastatic Niche11:41

Methods for Culturing Human Femur Tissue Explants to Study Breast Cancer Cell Colonization of the Metastatic Niche

Published on: March 15, 2015

12.8K

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.7K
The Colonization of Land02:22

The Colonization of Land

Changes in the environment of the early Earth drove the evolution of organisms. As prokaryotic organisms in the oceans began to photosynthesize, they produced oxygen. Eventually, oxygen saturated the oceans and entered the air, resulting in an increase in atmospheric oxygen concentration, known as the oxygen revolution approximately 2.3 billion years ago. Therefore, organisms that could use oxygen for cellular respiration had an advantage. More than 1.5 years ago, eukaryotic cells and...
37.4K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.0K
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
836
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
969
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
53.6K