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Bone health-promoting bioactive peptides.

Chang-Bum Ahn1, Jae-Young Je2

  • 1Division of Food and Nutrition, Chonnam National University, Gwangju, 61186, Republic of Korea.

Journal of Food Biochemistry
|July 30, 2019
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Bioactive peptides from food proteins show promise for improving bone health by balancing bone formation and resorption. Further research is needed to confirm their safety and efficacy in humans.

Keywords:
bioactive peptidebone health-promotingenzymatic hydrolysis

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Area of Science:

  • Biochemistry
  • Nutrition Science
  • Bone Biology

Background:

  • Bone health relies on a delicate balance between bone formation and resorption.
  • Disruptions in this balance can lead to bone diseases like osteoporosis and fragility fractures.
  • Bioactive peptides, derived from proteins, are emerging as potential agents to promote bone health.

Purpose of the Study:

  • To review existing literature on peptides that exhibit bone health-promoting effects.
  • To explore the biochemical mechanisms and production methods of these bioactive peptides.
  • To assess the practical applications of bioactive peptides as functional food ingredients and nutraceuticals.

Main Methods:

  • Literature review of scientific articles on bioactive peptides and bone health.
  • Analysis of studies demonstrating in vitro and in vivo effects of peptides on bone models.
  • Discussion of peptide production via enzymatic hydrolysis of food proteins.

Main Results:

  • Accumulating evidence indicates that peptides from endogenous and food proteins can enhance bone health.
  • Bioactive peptides have demonstrated positive effects in animal models of osteoporosis and fractures.
  • These peptides are commercially available and derived from food proteins through enzymatic hydrolysis.

Conclusions:

  • Bioactive peptides show potential as functional food ingredients and nutraceuticals for bone health.
  • Their ability to promote bone health is supported by in vitro and in vivo studies.
  • Further evaluation of their role and safety in human subjects is crucial before widespread commercialization.