1 H-31 P magnetic resonance spectroscopy: effect of biotin in multiple sclerosis
Carole Guillevin1,2, Pierre Agius1,3, Mathieu Naudin1,2
1DACTIM-MIS Team - LMA CNRS 7348, Poitiers University Medical Center, Poitiers Cedex, France.
Abstract:
Biotin is thought to improve functional impairment in progressive multiple sclerosis (MS) by upregulating bioenergetic metabolism. We enrolled 19 patients suffering from progressive MS (5 primary and 14 secondary Progressive-MS). Using cerebral multinuclear magnetic resonance spectroscopy (MMRS) and clinical evaluation before and after 6 months of biotin cure, we showed significant modifications of: PME/PDE, ATP, and lactate resonances; an improvement of EDSS Neuroscore. Our results are consistent with metabolic pathways concerned with biotin action and could suggest the usefulness of MMRS for monitoring.
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