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Updated: Jan 21, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
13.7K
Bone-targeted therapy in castration-resistant prostate cancer: where do we stand?
Juan Gómez Rivas1,2, Diego M Carrion3,4, Mario Alvarez-Maestro3,4
1Department of Urology, La Paz University Hospital, Madrid, Spain - juangomezr@gmail.com.
Summary
Bone-targeted agents (BTAs) improve outcomes in metastatic castration-resistant prostate cancer (mCRPC) when combined with life-prolonging therapies. Further research will refine optimal BTA strategies and explore novel agents like PSMA-targeted therapies for mCRPC management.
Area of Science:
- Oncology
- Pharmacology
- Radiopharmaceuticals
Background:
- Metastatic castration-resistant prostate cancer (mCRPC) treatment has advanced significantly.
- Bone-targeted agents (BTAs) combined with life-prolonging therapies improve clinical benefit.
- This review assesses BTAs in the evolving landscape of mCRPC management.
Purpose of the Study:
- Provide an overview of BTA data in mCRPC.
- Critically assess the use of BTAs in mCRPC.
- Evaluate novel targeted therapies for mCRPC.
Main Methods:
- Non-systematic literature review.
- Keywords: "castration-resistant prostate cancer" and "bone-targeted therapy".
Main Results:
- Zoledronic acid and denosumab reduce skeletal-related events (SREs) in mCRPC.
- Optimal timing for bisphosphonate/denosumab initiation requires further determination.
- Radium-223 (Ra-223) use is restricted; PSMA-targeted radioligand therapy (RLT) agents are under investigation.
Conclusions:
- Reducing skeletal morbidity is key in mCRPC palliative care.
- Optimizing BTA integration requires further data on dosing and combinations.
- Novel PSMA-targeted agents offer potential theranostic applications for prostate cancer (PCa).
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