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Updated: Jan 21, 2026

Orthotopic Mouse Model of Colorectal Cancer
Published on: December 4, 2007
Prognostic significance of periostin in colorectal cancer
Xingming Deng1, Sheng Ao1, Jianing Hou1
1Department of Gastrointestinal Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.
Abstract:
Accumulating evidence suggests that periostin is frequently upregulated in tissue injury, inflammation, fibrosis and tumor progression. Periostin expression in cancer cells can promote metastatic potential of colorectal cancer (CRC) via activating PI3K/Akt signaling pathway. Moreover, periostin is observed mainly in tumor stroma and cytoplasm of cancer cells, which may facilitate aggressiveness of CRC. In this review, we summarize information regarding periostin to emphasize its role as a prognostic marker of CRC.
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