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Related Experiment Video

Updated: Jan 21, 2026

Minimally Invasive Muscle Embedding MIME - A Novel Experimental Technique to Facilitate Donor-Cell-Mediated Myogenesis

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Metabolic Reprogramming Promotes Myogenesis During Aging.

Roberta Belli¹, Agnese Bonato², Luciana De Angelis³

¹Department of Translational and Precision Medicine (Formerly Department of Clinical Medicine), Sapienza University of Rome, Rome, Italy.

Frontiers in Physiology

|July 30, 2019

Summary

Metabolic modulators like trimetazidine (TMZ) can stimulate muscle regeneration and mitochondrial function in aging mice. This research suggests a potential non-invasive therapy to combat age-related muscle loss (sarcopenia).

Keywords:

aging metabolic reprogramming metabolism mitochondria myogenesis neuromuscular activity sarcopenia trimetazidine

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Published on: September 20, 2016

Area of Science:

Gerontology
Muscle Biology
Metabolic Research

Background:

Sarcopenia, the age-related loss of muscle mass and strength, is linked to impaired myogenesis and mitochondrial dysfunction.
Understanding the interplay between myogenesis and metabolism is crucial for addressing age-related muscle decline.

Purpose of the Study:

To investigate the effect of the metabolic modulator trimetazidine (TMZ) on myogenesis in aging skeletal muscle.
To explore the potential of metabolic reprogramming as a therapeutic strategy for sarcopenia.

Main Methods:

Treatment of aged mice (22 months old) with trimetazidine (TMZ) for 12 consecutive days.
Analysis of myogenic gene expression, mitochondrial protein levels, and oxidative metabolism in skeletal muscle.
In vitro assessment of metabolic modulators, including 5-Aminoimidazole-4-Carboxamide Ribofuranoside (AICAR), on skeletal muscle progenitor differentiation.

Main Results:

TMZ treatment stimulated myogenic gene expression in aged mouse skeletal muscle.
TMZ increased mitochondrial protein levels and enhanced oxidative metabolism in aged muscles.
Metabolic modulators, including AICAR, promoted skeletal muscle progenitor differentiation in vitro.

Conclusions:

Reprogramming cellular metabolism stimulates myogenesis and mitochondrial protein synthesis in aging skeletal muscle.
Metabolic modulation represents a promising non-invasive therapeutic approach to improve muscle quality and counteract sarcopenia in the elderly.