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Antibacterial Effect of Silver Nanoparticles Synthesized Using Murraya koenigii (L.) against Multidrug-Resistant

Faizan Abul Qais1, Anam Shafiq1,2, Haris M Khan2

  • 1Department of Agricultural Microbiology, Faculty of Agricultural Sciences, Aligarh Muslim University, Aligarh, UP 202002, India.

Bioinorganic Chemistry and Applications
|July 30, 2019
PubMed

Insights

Green synthesized silver nanoparticles from Murraya koenigii leaves show potent antibacterial activity against multidrug-resistant pathogens. These novel nanoparticles effectively inhibit the growth of problematic bacteria like ESBL-producing E. coli and MRSA in vitro.

Area of Science:

  • Nanotechnology
  • Microbiology
  • Materials Science

Background:

  • Multidrug resistance (MDR) in bacterial pathogens poses a significant global health threat, complicating chemotherapy.
  • Extended-spectrum β-lactamase (ESβL)-producing enteric bacteria and methicillin-resistant Staphylococcus aureus (MRSA) are key MDR pathogens demanding novel therapeutic strategies.

Purpose of the Study:

  • To synthesize silver nanoparticles (AgNPs) using an aqueous extract of Murraya koenigii (MK) leaves.
  • To characterize the synthesized MK-AgNPs and evaluate their in vitro antibacterial efficacy against ESβL-producing enteric bacteria and MRSA.

Main Methods:

  • Green synthesis of silver nanoparticles using Murraya koenigii leaf extract.
  • Characterization of MK-AgNPs via UV-vis spectroscopy, FTIR, XRD, SEM, and TEM.
  • Antibacterial activity assessment using disc-diffusion assay, determination of Minimum Inhibitory Concentration (MIC), and Minimum Bactericidal Concentration (MBC).

Main Results:

  • Spheroidal MK-AgNPs with a particle size of 5-20 nm were successfully synthesized, containing 60.86% silver.
  • MK-AgNPs demonstrated significant inhibition zones against ESβL-producing bacteria and MRSA.
  • MIC values ranged from 16-64 μg/ml for tested pathogens, with significant growth inhibition observed in kinetic studies.

Conclusions:

  • Green synthesized MK-AgNPs exhibit promising in vitro antibacterial efficacy against critical MDR pathogens.
  • The study highlights the potential of MK-AgNPs as a therapeutic agent against multidrug-resistant bacterial infections.
  • Further in vivo studies are warranted to explore the therapeutic potential of these nanoparticles.

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