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Updated: Jan 21, 2026

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue
Published on: May 1, 2019
Novel Agents in Heavily Pretreated Metastatic Gastric Cancer: More Shadows Than Lights
Giandomenico Roviello1, Alberto D'Angelo2, Raheleh Roudi3
1Department of Health Sciences, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy.
Abstract:
Metastatic gastric cancer is still a disease with a poor prognosis. Recently, different novel agents (e.g., apatinib, nivolumab, TAS-102) have demonstrated a survival advantage compared with placebo for patients with heavily pretreated metastatic gastric cancer. Although the possible availability of active agents may be a desirable option in a very poor therapeutic scenario, clinical data from the recent studies with these drugs raise yet controversial issues. The purpose of this review is to briefly summarize the results of these novel drugs focusing on the limitations that bring some shadows on their positive therapeutic results.
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