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Author Spotlight: Advanced Ex Vivo Model for Investigating Cancer-Adipose Microenvironment Interaction
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Humanized Anti-hepatocyte Growth Factor Monoclonal Antibody (YYB-101) Inhibits Ovarian Cancer Progression

Hyun Jung Kim1,2, Sukmook Lee3, Yong-Seok Oh4

  • 1Research Institute, National Cancer Center, Goyang-si, South Korea.

Frontiers in Oncology
|July 30, 2019
PubMed

Insights

A new antibody therapy, YYB-101, targeting hepatocyte growth factor (HGF), shows promise for advanced ovarian cancer. Combined with chemotherapy, it significantly improved survival in preclinical models.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunotherapy

Background:

  • Advanced ovarian cancer survival rates are limited by current chemotherapy.
  • Hepatocyte growth factor (HGF) plays a critical role in ovarian cancer cell migration and invasion.

Purpose of the Study:

  • To evaluate the efficacy of YYB-101, a humanized monoclonal anti-HGF antibody, in inhibiting ovarian cancer growth and metastasis.
  • To assess the combined therapeutic effect of YYB-101 and paclitaxel in ovarian cancer models.

Main Methods:

  • Assessed YYB-101's effect on HGF receptor c-MET phosphorylation in ovarian cancer cells (SKOV3, A2780).
  • Evaluated YYB-101's impact on cancer cell migration and invasion in vitro.
  • Tested the synergistic effect of YYB-101 and paclitaxel in an in vivo ovarian cancer mouse xenograft model.

Main Results:

  • YYB-101 effectively suppressed c-MET phosphorylation and inhibited ovarian cancer cell migration and invasion.
  • The combination of YYB-101 and paclitaxel demonstrated synergistic inhibition of tumor growth.
  • Combined therapy significantly increased overall survival (OS) compared to single-agent treatments.

Conclusions:

  • YYB-101 exhibits therapeutic potential for ovarian cancer by targeting the HGF/c-MET pathway.
  • Combining YYB-101 with conventional chemotherapy, such as paclitaxel, offers a promising strategy to improve treatment outcomes for advanced ovarian cancer.
Keywords:
HGFYYB-101humanized monoclonal antibodymetastasisovarian cancer

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