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Updated: Jan 21, 2026

Production and Targeting of Monovalent Quantum Dots
Published on: October 23, 2014
A smart drug-delivery nanosystem based on carboxylated graphene quantum dots for tumor-targeted chemotherapy
Zhen Li1, Jialong Fan1, Chunyi Tong1
1College of Biology, Hunan Province Key Laboratory of Plant Functional Genomics & Developmental Regulation, Hunan University, Changsha, 410082, PR China.
Abstract:
Aim: Constructing a new drug-delivery system using carboxylated graphene quantum dots (cGQDs) for tumor chemotherapy in vivo. Materials & methods: A drug-delivery system was synthesized through a crosslink reaction of cGQDs, NH2-poly(ethylene glycol)-NH2 and folic acid. Results: A drug delivery system of folic acid-poly(ethylene glycol)-cGQDs was successfully constructed with ideal entrapment efficiency (97.5%) and drug-loading capacity (40.1%). Cell image indicated that the nanosystem entered into human cervical cancer cells mainly through macropinocytosis-dependent pathway. In vivo experiments showed the outstanding antitumor ability and low systemic toxicity of this nanodrug-delivery system. Conclusion: The newly developed drug-delivery system provides an important alternative for tumor therapy without causing systemic adverse effects.
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