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Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

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Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
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DPP-4 Levels Are Increased in Subjects with Poor Sleep Quality.

Karla Montelongo-Rodríguez1, Rafael Almendra-Pegueros1, Liliana Valencia-Sánchez2

  • 1Laboratorio de Investigacion Traslacional en Farmacologia, Departamento de Epidemiologia Clinica, Facultad de Medicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, SLP, Mexico.

Metabolic Syndrome and Related Disorders
|July 30, 2019
PubMed
Summary

Poor sleep quality is linked to higher dipeptidyl peptidase 4 (DPP-4) levels, suggesting a potential early indicator for metabolic disorders. This highlights the importance of addressing sleep disturbances for overall health.

Keywords:
cardiometabolic riskdipeptidyl peptidase 4obesitysleep disorderssleep hygiene

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Area of Science:

  • Metabolic Health
  • Sleep Science
  • Biochemistry

Background:

  • Sleep disturbances affect up to 30% of the population, often unrecognized and untreated.
  • Elevated dipeptidyl peptidase 4 (DPP-4) levels have been observed after total sleep deprivation.
  • Poor sleep quality can negatively impact overall health and may be associated with metabolic dysfunction.

Purpose of the Study:

  • To compare serum dipeptidyl peptidase 4 (DPP-4) levels between healthy individuals with adequate sleep and those with poor sleep quality requiring medical attention.
  • To investigate the potential of DPP-4 as a biomarker for sleep-related metabolic disturbances.

Main Methods:

  • A cross-sectional study included 57 healthy adults (18-70 years) with low cardiometabolic risk, excluding those with pre-existing conditions.
  • Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) to categorize participants.
  • Serum DPP-4 levels were quantified using Enzyme-Linked Immunosorbent Assay (ELISA).

Main Results:

  • 66.6% of participants were overweight or obese, with high abdominal circumference values.
  • Over half (56.1%) of the subjects were classified as having poor sleep quality (PSQI score 8.3 ± 4.1) warranting medical attention.
  • Significantly higher serum DPP-4 levels were found in individuals with poor sleep quality (2385.0 ± 2082.0 pg/mL) compared to those with good sleep quality (1716.7 ± 1261.7 pg/mL) (P=0.035).

Conclusions:

  • Elevated DPP-4 levels in individuals with poor sleep quality may serve as an early indicator of metabolic disorders.
  • These findings underscore the need for further investigation into the relationship between sleep quality and metabolic health.
  • Addressing sleep disturbances could be crucial for early detection and management of metabolic health issues.