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Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression
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Relating diffusion tensor imaging measurements to microstructural quantities in the cerebral cortex in multiple

Rebecca McKavanagh1, Mario Torso1, Mark Jenkinson2

  • 1Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.

Human Brain Mapping
|July 30, 2019
PubMed
Summary
This summary is machine-generated.

Diffusion MRI measures in the brain correlate with its microstructural organization. These novel diffusion MRI metrics may serve as biomarkers for neurological disorders like multiple sclerosis.

Keywords:
cortexdiffusion tensor imagingminicolumnsmultiple sclerosispostmortem

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Area of Science:

  • Neuroimaging
  • Neuroscience
  • Biomarkers

Background:

  • Anisotropic diffusion in the cerebral cortex may reflect its underlying columnar cytoarchitecture and myeloarchitecture.
  • Understanding this relationship could yield biomarkers for disease-related changes.

Purpose of the Study:

  • To investigate if diffusion magnetic resonance imaging (dMRI) measures correlate with cortical microstructural organization.
  • To explore the potential of these dMRI measures as biomarkers for neurological disorders.

Main Methods:

  • Compared postmortem dMRI scans of multiple sclerosis (MS) brains with histology from the same regions.
  • Assessed cortical minicolumnar structure (cell bodies, axon bundles) and diffusivity measures (mean diffusivity, fractional anisotropy, diffusion angle, radial/parallel components).

Main Results:

  • Correlations found between cellular minicolumn features and diffusion angle in specific cortical areas.
  • Axon bundle features correlated with diffusion angle and parallel component in certain regions.
  • Cortical diffusion measures showed group differences between MS and control brains, and regional variations.

Conclusions:

  • Cortical microstructural organization influences diffusion MRI measures.
  • Novel dMRI measures may serve as surrogates for cortical organization.
  • These measures show potential as biomarkers for detecting regional changes in neurological disorders.